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Russian to English - Standard rate: 0.10 USD per word / 30 USD per hour English to Russian - Standard rate: 0.10 USD per word / 30 USD per hour English to Ukrainian - Standard rate: 0.10 USD per word / 30 USD per hour Russian to Ukrainian - Standard rate: 0.06 USD per word / 20 USD per hour Ukrainian to Russian - Standard rate: 0.06 USD per word / 20 USD per hour
Ukrainian to English - Standard rate: 0.10 USD per word / 30 USD per hour
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Sample translations submitted: 1
English to Russian: Effect of St John,s wort on imatinib mesylate pharmacokinetics. General field: Medical Detailed field: Medical: Pharmaceuticals
Source text - English OBJECTIVE: Imatinib is a potent inhibitor of the Bcr-Abl and kit tyrosine kinases and is approved for the treatment of Philadelphia chromosome-positive chronic myelogenous leukemia and gastrointestinal stromal tumors. Because imatinib is predominantly metabolized by cytochrome P450 (CYP) 3A4, its pharmacokinetics may be altered when it is coadministered with drugs or herbs (eg, St John's wort) that modulate CYP3A4 activity.Thus we examined the effects of St John's wort on imatinib pharmacokinetics. METHODS: This 2-period, open-label, fixed-sequence study was completed by 12 healthy subjects (6 men and 6 women) aged between 20 and 51 years. Each subject received 400 mg imatinib orally on study day 1, St John's wort (300 mg 3 times daily) on days 4 to 17, and 400 mg imatinib again on day 15. Serial blood samples were obtained over a 72-hour period after each imatinib dose. Imatinib and N -desmethyl-imatinib (CGP 74588) were quantified in plasma by liquid chromatography-mass spectrometry. RESULTS: St John's wort administration increased imatinib clearance by 43% ( P < .001), from 12.5 /- 3.6 L/h to 17.9 /- 5.6 L/h; imatinib area under the concentration versus time curve (AUC) extrapolated to infinity was decreased by 30%, from 34.5 /- 9.5 microg . h/mL to 24.2 /- 7.0 microg . h/mL ( P < .001). Imatinib half-life (12.8 hours versus 9.0 hours) and maximum concentration (C max ) (2.2 microg/mL versus 1.8 microg/mL) were also significantly decreased ( P < .005). N -desmethyl-imatinib C max was increased from 285 /- 95 ng/mL to 318 /- 95 ng/mL during St John's wort dosing, but the AUC from 0 to 72 hours was not altered. CONCLUSIONS: These data indicate that St John's wort increases imatinib clearance. Thus patients taking imatinib should avoid taking St John's wort. Concomitant use of enzyme inducers, including St John's wort, may necessitate an increase in the imatinib dose to maintain clinical effectiveness.
Translation - Russian ЦЕЛЬ. Иматиниб является сильным ингибитором Bcr-Abl и kit-тирозинкиназ. Он утвержден для терапии "филадельфийского" хромосом-позитивного хронического миелолейкоза и желудочно-кишечных стромальных опухолей. По причине того, что метаболизм иматиниба происходит в основном за счет цитохрома P450 (CYP) 3A4, его фармакокинетика может изменяться, если принимать одновременно с препаратами или лекарственными растениями (например, зверобоем пронзеннолистным), модулирующими активность CYP3A4. Поэтому мы исследовали влияние зверобоя пронзеннолистного на фармакокинетику иматиниба. МЕТОДЫ. Данное 2-периодное, открытое исследование с жестко заданной последовательностью было проведено с участием 12 здоровых субъектов (6 мужчин и 6 женщин) в возрасте 20—51 лет. Каждый субъект принимал 400 мг иматиниба перорально в 1-й день исследования, зверобой пронзеннолистный (по 300 мг 3 раза ежедневно) с 4-го по 17-й день и повторно 400 мг иматиниба на 15-й день. Последовательно брались пробы крови через 72 часа вслед за каждой дозой иматиниба. Методами жидкостной хроматографии и масс-спектрометрии были рассчитаны уровни иматиниба и N-десметил-иматиниба (CGP 74588) в плазме. РЕЗУЛЬТАТЫ. Принятие зверобоя пронзеннолистного повысило очистку иматиниба на 43 % (P < 0,001): с 12,5 /– 3,6 л/ч до 17,9 /– 5,6 л/ч; площадь иматиниба под кривой концентрации от времени (AUC), экстраполированная до бесконечности, уменьшилась на 30 %: с 34,5 /– 9,5 мкг·ч/мл до 24,2 /– 7,0 мкг·ч/мл ( P < 0,001). Также значительно снизились (P < 0,005) период полувыведения иматиниба (12,8 часов по сравнению с 9,0 часами) и максимальная концентрация (C max) (2,2 мкг/мл по сравнению с 1,8 мкг/мл). C max N-десметил-иматиниба выросла с 285 /– 95 нг/мл до 318 /– 95 нг/мл в процессе принятия доз зверобоя пронзеннолистного, но AUC от нуля до 72 часов не изменилась. ВЫВОДЫ. Эти сведения говорят о том, что зверобой пронзеннолистный способствует очищению иматиниба. Поэтому пациенты, лечащиеся иматинибом, должны избегать принятия зверобоя пронзеннолистного. Одновременное использование индукторов энзимов, включая зверобой пронзеннолистный, может вызвать необходимость увеличения дозы для поддержания клинической эффективности.
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Experience
Years of experience: 18. Registered at ProZ.com: Aug 2010.
Adobe Acrobat, Adobe Photoshop, AutoCAD, DejaVu, Dreamweaver, memoQ, Microsoft Excel, Microsoft Word, Translation Workspace, Passolo, Powerpoint, Trados Studio
2007 Master’s Degree – Polymer Materials Synthesis and Processing
Qualification: Chemical Research Engineer (Master of Science in Engineering)
National Technical University ‘Kharkiv Polytechnic Institute’
Honors and Awards: Diploma with distinction
2005 Bachelor’s Degree – Chemical Technology & Engineering.
Qualification: Chemical Process Engineer (Bachelor of Engineering)
National Technical University ‘Kharkiv Polytechnic Institute’
Honors and Awards: Diploma with distinction
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CAREER HISTORY:
2005-present Freelance translator
2011-2012 ‘Kenaz Translations’ – Translation and Localization company
Staff translator
2009-2011 ‘RBK-Translation’ – Language services
Staff proofreader
2009-2010 ‘Student Course W’ – Course work agency
Author of course and degree works for English-speaking students
2007-2010 LLC ‘Zemlya-1’ – Land-resource Management Company
Specialist of land-resources
2006-2007 Magazine ‘Mobilux’ – Mobile technologies
Editor-in-chief assistant
2005-2006 Scientific and Production Enterprise ‘Laurit’ – Paint and varnish manufacturing
Specialist Engineer
2003-2007 National Technical University ‘Kharkiv Polytechnic Institute’ (part-time job)
Junior researcher (patent search on chemical subjects in world patent databases of Internet, translation of science and technical articles for joint science works with my department dean in the University).
