GLOSSARY ENTRY (DERIVED FROM QUESTION BELOW) | ||||||
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07:55 May 26, 2017 |
English to Russian translations [PRO] Medical - Medical: Pharmaceuticals | |||||||
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| Selected response from: Elena Doroshenko Russian Federation | ||||||
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Summary of answers provided | ||||
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4 +3 | популяция (совокупность пациентов) согласно фактически полученному лечению |
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as-treated population популяция (совокупность пациентов) согласно фактически полученному лечению Explanation: популяция (совокупность пациентов) согласно фактически полученному лечению http://www.multitran.ru/c/m.exe?l1=1&l2=2&s=As-Treated popul... The formal definition of the "Intention to Treat" is usually referred to the one suggested by Fisher, LD et al. in “Intention to treat in clinical trials in Statistical Issues in Drug Research and Development. Edited by Peace KE (1990)”. Intention to Treat population “Includes all randomized patients in the groups to which they were randomly assigned, regardless of their adherence with the entry criteria, regardless of the treatment they actually received, and regardless of subsequent withdrawal from treatment or deviation from the protocol”. In other words, ITT analysis includes every subject who is randomized according to randomized treatment assignment. It ignores noncompliance, protocol deviations, withdrawal, and anything that happens after randomization. ITT analysis is usually described as “once randomized, always analyzed”. ITT analysis is referred as ‘as randomized’ - the opposite of the term ‘as treated’. In majority of cases, if all randomized subjects receive their allocated treatments and if there is no randomization error, the ‘as treated’ analysis will be the same as 'as randomized' analysis. If some randomized subjects do not receive the randomly alloccated treatment and if there are randomization errors, ‘as treated’ population will be different from ITT population or 'as randomized' population. http://onbiostatistics.blogspot.ru/2013/09/as-treated-versus... |
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